Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.3
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
Most Useful Reviews
8
Normalises liver function
254 people found this helpful
I drink with my husband 2 course, excellent composition, well absorbed, works great. It helps to normalise liver function and improves sleep. Affects the nervous system positively, reduces anxiety and relieves stress. I noticed it improves my overall well-being. Don't fear high dosages as these are water-soluble vitamins; the body only takes what it needs, and the excess is excreted.
Read More
9
Normalises liver function
9 people found this helpful
Perfectly absorbed, these vitamins support the nervous system and help normalise liver function. There’s no need to worry about large dosages, as they are water-soluble, meaning the body uses what it requires and excretes the rest. They also improve sleep, reduce anxiety, relieve stress, and alleviate muscle weakness.
Read More
9
Supports overall energy
6 people found this helpful
This super complex of bioavailable B vitamins is excellent! Although urine may turn yellow, it indicates the supplement's effectiveness. As they are water-soluble, there’s no risk of overdose. Taking two daily supports the nervous system, liver, and overall energy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Normalises liver function
254 people found this helpful
I drink with my husband 2 course, excellent composition, well absorbed, works great. It helps to normalise liver function and improves sleep. Affects the nervous system positively, reduces anxiety and relieves stress. I noticed it improves my overall well-being. Don't fear high dosages as these are water-soluble vitamins; the body only takes what it needs, and the excess is excreted.
Read More
9
Normalises liver function
9 people found this helpful
Perfectly absorbed, these vitamins support the nervous system and help normalise liver function. There’s no need to worry about large dosages, as they are water-soluble, meaning the body uses what it requires and excretes the rest. They also improve sleep, reduce anxiety, relieve stress, and alleviate muscle weakness.
Read More
9
Supports overall energy
6 people found this helpful
This super complex of bioavailable B vitamins is excellent! Although urine may turn yellow, it indicates the supplement's effectiveness. As they are water-soluble, there’s no risk of overdose. Taking two daily supports the nervous system, liver, and overall energy.
Read More
9
Enhances well-being
2 people found this helpful
These vitamins effectively normalise liver function and support the nervous system. They can be taken in large dosages without concern due to their water-soluble nature. They enhance sleep quality, reduce anxiety, relieve tension, and improve overall well-being.
Read More
9
Excellent for liver
2 people found this helpful
This B complex is superb for liver health, and I find this brand to be truly outstanding.
Read More
Frequently Asked Questions
7.5
Boosts energy levels
1 people found this helpful
According to information online, vitamin B complex is vital for maintaining cell biochemical functions, including metabolism, hematopoiesis, nerve protection, detoxification, and enhancing immunity. It can help prevent liver cancer and other types of cancer. I specifically purchased a bottle to try with my family. After a week, everyone feels much more energetic than before! I will continue using it.
6
Restores skin health
1 people found this helpful
I purchased this B vitamin complex to improve my skin condition and tackle allergic reactions. If I sweat, irritation and redness occur, possibly leading to rashes. I combine it with magnesium for better absorption. After two weeks of use, my skin has fully healed—no redness or rashes! B vitamins accumulate in the liver for long-lasting effects. However, I advise consulting a doctor. The packaging was decent, but I found vitamin dust inside due to loosely sealed capsules, which is why I deducted a star. Nonetheless, the vitamins truly work!
0
Liver ache experienced
5 people found this helpful
Unfortunately, these vitamins did not suit me. After three or four doses, my liver ached, my urine turned bright yellow, and I experienced severe vomiting in the evenings. I stopped taking them immediately. An endocrinologist prescribed different B vitamins instead, which would likely have suited me better. Please consider reading more reviews.
8
Normalises liver function
254 people found this helpful
I drink with my husband 2 course, excellent composition, well absorbed, works great. It helps to normalise liver function and improves sleep. Affects the nervous system positively, reduces anxiety and relieves stress. I noticed it improves my overall well-being. Don't fear high dosages as these are water-soluble vitamins; the body only takes what it needs, and the excess is excreted.
9
Good for liver function
1 people found this helpful
B group vitamins improve energy metabolism, reducing fatigue while enhancing nervous system functions, strengthening immunity, and maintaining skin, hair, and liver health. Life Extension produces high-quality vitamins in convenient packaging with optimal dosages. I highly recommend them; they are worth the investment!
5
Good for liver normalisation
16 people found this helpful
It aids in recovering from post-COVID conditions, supports the nervous system, and is a healthy support for liver normalisation.
7.5
Effective for fatigue recovery
5 people found this helpful
I discovered these vitamins from a gynecologist due to low liver function and was advised to use B group supplements for fatigue and skin improvement. I'm grateful for their availability at a reasonable price. They have indeed aided in my recovery from fatigue, especially since I walk 10,000 steps daily, leaving me exhausted. This supplement genuinely helps improve my condition.
9
Normalises liver function
9 people found this helpful
Perfectly absorbed, these vitamins support the nervous system and help normalise liver function. There’s no need to worry about large dosages, as they are water-soluble, meaning the body uses what it requires and excretes the rest. They also improve sleep, reduce anxiety, relieve stress, and alleviate muscle weakness.
0
High doses harmful
2 people found this helpful
I do not recommend these vitamins. The doses are excessively high, surpassing bodily needs by over 10,000 times. This could potentially harm the liver and nervous system. I've attached images showcasing the body's required dosages to illustrate the vast discrepancy.
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
References
- Ciftel S, Ciftel S, Altuner D, Huseynova G, Yucel N, et al. Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats. BMC Pharmacol Toxicol. 2025;26:67. 10.1186/s40360-025-00901-7
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. 10.1038/s41467-024-54826-6
- Zhu J, Liao X, Du L, Lv P, Deng J. Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1426103. 10.3389/fendo.2024.1426103
- Shen H, Zhou L, Yang Y, Shu H, Wu D, et al. The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatol Commun. 2025;9. 10.1097/HC9.0000000000000599
